Jana Fleischer loves her life - wonderful family, best sister in the world, awesome soon to be sister-in-law, fabulous job, and a never-ending stream of men to chew through and spit out. So what if everyone says she’s too picky and she’s never had a real relationship? When a chance meeting with Brooke Donnelly leaves Jana literally and figuratively off-balance, it doesn’t take long for her initial annoyance to turn into the first sparks of friendship.

Ellie Fisher loves most things about being a nurse in the emergency department . . . just not working with Regina Novak, an icy attending physician who acts as if she's God's gift to medicine. The dislike is completely mutual. Regina thinks Ellie is a starry-eyed romantic with a sentimental attitude that has no place at work. When Regina gets talked into volunteering at a singles auction, Ellie accidentally bids on her—and ends up winning. Oops! Since the money raised is for a good cause, they reluctantly decide to go through with the dates.

Accountant Samantha Ennis craves order and structure. As the bookkeeper at the boutique advertising agency she owns with her three best friends, it's her job to apply logic to the chaos. When one of those best friends, laid-back Hunter Blair, moves in to share her loft apartment, Sam's carefully organized world is thrown wildly askew.

Librarian Syd Murphy flees the carnage of a failed marriage by accepting an 18-month position in Jericho - a small town in the Appalachian Mountains of Virginia. Her plans to hide out and heal her wounds fall by the wayside as she gets drawn into the daily lives of the quirky locals. She becomes fast friends with Maddie Stevenson, the enigmatic physician who has returned to the backcountry community to take over her late father's medical practice.

Hannah Martin has an unusual job: she's a professional cuddler. While she has a big heart for her clients, she hasn't found someone special to snuggle up to in her personal life. Winter Sullivan isn't looking for love. She's an aloof workaholic who's built walls of ice around herself. She would rather drive toothpicks under her fingernails than cuddle, and she certainly doesn't want to share her space with anyone. When Winter's estranged father dies, he leaves her one last surprise: she and Hannah, a perfect stranger, will inherit a building together.