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The Philadelphia Chromosome

A Mutant Gene and the Quest to Cure Cancer at the Genetic Level

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The Philadelphia Chromosome

Written by: Jessica Wapner
Narrated by: Heather Henderson
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About this listen

Almost daily, headlines announce newly discovered links between cancers and their genetic causes. Science journalist Jessica Wapner vividly relates the backstory behind those headlines, reconstructing the crucial breakthroughs, explaining the science behind them, and giving due to the dozens of researchers, doctors, and patients whose curiosity and determination restored the promise of a future to the more than 50,000 people diagnosed each year with chronic myeloid leukemia (CML). It is an astonishing tale that will provide victims of other cancers and their loved ones realistic hope that cures may yet be found in their lifetimes.

The Philadelphia Chromosome charts the milestones that led to present-day cancer treatment and tells the inspiring story of the dedicated men and women who, working individually and in concert, have sought to plum the mysteries of the human genome in order to conquer those deadly and most feared diseases called cancer.

©2013 Jessica Wapner (P)2013 HighBridge Company. Biological Sciences Cancer Medicine & Health Care Industry Science

Critic Reviews

“[Wapner’s] gracefully written history skillfully combines both the science and humanity of this fascinating search for a cure for chronic myeloid leukemia.” ( Publishers Weekly)
“The story of the Philadelphia chromosome is truly the story of modern cancer biology. . . . Jessica Wapner stitches the whole story together with tenacity, diligence (and humor). This is a wonderful, readable, and highly informative book.” (Siddhartha Mukherjee, Pulitzer Prize-winning author of The Emperor of all Maladies)

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Reminiscing the Chhotu chromosome

Having spent more than 15 years with this chromosome, it was a must read for me. Not only to re-live the moments of having many Firsts in my lab, like FISH, presenting the paper in clinical meeting, witnessing 10+ years survivors, rejoicing successful bone marrow transplantation with the dedicated medical team; but also to teach the masters students, to give them a feel of doing science!
Quite a few important stories of the field are missing however.
Excellent account of grit that lead to this path changing scenario of cancer treatment today.

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