A comprehensive analysis of hundreds of studies on topical skin treatments for atopic dermatitis, a chronic inflammatory skin condition, found that calcineurin inhibitors such as pimecrolimus and tacrolimus, as well as moderate-potency topical corticosteroids, are among the most effective options. These medications effectively reduce itch, flares, and sleep disturbances while minimizing serious side effects. The study also revealed a surprising finding that applying topical treatments once daily instead of twice daily does not significantly affect their efficacy. While the research suggests promising treatment options, individual responses may vary, and it's crucial to consult with a dermatologist for personalized guidance.